- Title
- Carbimazole/methimazole embryopathy in siblings: a possible genetic susceptibility
- Creator
- Goel, Himanshu; Dudding, Tracy
- Relation
- Birth Defects Research Part A: Clinical and Molecular Teratology Vol. 97, Issue 11, p. 755-758
- Publisher Link
- http://dx.doi.org/10.1002/bdra.23200
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2013
- Description
- BACKGROUND: The teratogenic effects of antenatal exposure of antithyroid drugs, carbimazole and methimazole have been well reported in the literature. These comprise of typical facial features and a wide variety of malformations such as choanal atresia, tracheo-esophageal anomalies, congenital heart disease and ectodermal defects. However, the longitudinal studies have failed to establish the consistent teratogenicity of these drugs. CASES: We report here two siblings with physical features consistent with carbimazole/methimazole embryopathy. We also describe previously unreported minor dental anomalies in these siblings with antenatal exposure of carbimazole. CONCLUSION: Generally, only a small proportion of prenatally exposed children have the typical manifestations, and the presence in siblings supports a possible hereditary susceptibility to carbimazole/ methimazole embryopathy. This highlights the importance of recognizing this diagnosis before a subsequent pregnancy.
- Subject
- carbimazole; methimazole; choanal atresia; dysmorphism; congenital abnormalities; embryopathy
- Identifier
- http://hdl.handle.net/1959.13/1318720
- Identifier
- uon:23675
- Identifier
- ISSN:1542-0752
- Rights
- This is the peer reviewed version of the following article: Goel, H. and Dudding, T. (2013), Carbimazole/methimazole embryopathy in siblings: A possible genetic susceptibility. Birth Defects Research Part A: Clinical and Molecular Teratology, 97: 755–758, which has been published in final form at doi:10.1002/bdra.23200. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
- Language
- eng
- Full Text
- Reviewed
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